Six PER1, 2 and 3 genetic markers the indel rs57875989 and five single nucleotide polymorphisms (SNPs), rs2735611, rs2304672, rs934945, rs10462020, and rs228697, were genotyped, using TaqMan ® or regular polymerase chain reaction (PCR), in a Swedish CH case control material. Genetic variants of genes involved in the circadian rhythm such as Period Circadian Regulator 1, 2, and 3 ( PER1, 2 and 3) are hypothesized to have an effect on the rhythmicity of the attacks. ![]() For a majority of patients, the headache attacks occur at approximately the same time every day. One of the disorder’s most striking features is the reported diurnal rhythmicity of the attacks. ![]() ![]() ![]() The trigeminal autonomic cephalalgia, cluster headache (CH), is one of the most painful disorders known to man.
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